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Dr. Jiang-Fan Chen's team

Author: From: Time: 2018/9/27 8:53:17 [Print]

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Over the past 15 years Jiang-Fan Chen`s laboratory focused on understanding adenosine and adenosine receptor functions under physiological and pathophysiological conditions, with the goal to develop adenosine-based therapeutic treatments for Parkinson’s disease (PD) and retinopathy of prematurity.  Over the last decade, work from our laboratory made a significant contribution to the exciting development of the adenosine A2A receptor (A2AR) as a leading non-dopaminergic therapeutic target for PD, i) by providing the first experimental evidence for neuroprotection by caffeine and A2AR antagonists, offering the neurobiological basis for the inverse relationship between caffeine consumption and the risk of developing PD; ii) by demonstrating distinct cellular mechanisms for motor and neuroprotective effects of A2AR antagonists in PD models, indicating the possible involvement of both neuronal and astroglial A2ARs. iii) We have devoted significant effort to uncover the pro-cognitive function of inactivation of striatopallidal A2ARs in the control of a variety of cognitive outcome parameters ranging from working memory to reversal learning and habit formation.  More recently, our group recent investigation into the A2AR control of retinal vascularization led to the discovery of the abnormal A2AR signaling in retina as a therapeutic target for retinopathy of prematurity.  


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