Fundings

1. Expression profile and function of miRNAs in the wound healing of cornea epithelium. (NSFC, for Tu, L);

   
   

2. The role of LGR4 in the development of eyelid in mice. (NSFC, for Tu, L);

   
   

3. The function of LGR4 in eye development. (Key program of Zhejiang NSF, for Tu, L);

   
   

4. 4.The function of LGR4 in eye development. (program for new century excellent talents in university of ministry of education of China, for Tu, L);

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6. GPR48 regulates proliferation and migration of RPE cells. (Youth program of NSFC, for Hou, Q);

   
   

7. HGF/c-Met promotes migration and invasion of uveal melanoma cells. (Youth program of NSFC, for Wang, Z);

   
   

8. The mechanism of GPR48 regulated proliferation and migration of RPE cells. (General program of Zhejiang NSF, for Hou, Q);

   
   

9. GPR48 regulates the development of eyelid. (General program of Zhejiang NSF, for Wang, Z).

Selective Publications

1. Hou Q, Han S, Yang L, Chen S, Chen J, Ma N, et al. The Interplay of MicroRNA-34a, LGR4, EMT-Associated Factors, and MMP2 in Regulating Uveal Melanoma Cells. Invest Ophthalmol Vis Sci. 2019;60:4503-10.

   
   

2. Hou Q, Zhou L, Tang J, et al. LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells. PLoS One. 2016;11:e0168320.

   
   

3. Zhu J, Hou Q, Dong XD, et al. Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation. PLoS One. 2015;10:e0119599.

   
   

4. Zheng Z, Yan D, Chen X, et al. MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway. PLoS One. 2015;10:e0128751.

   
   

5. An J, Chen X, Chen W, et al. MicroRNA Expression Profile and the Role of miR-204 in Corneal Wound Healing. Invest Ophthalmol Vis Sci. 2015;56:3673-3683.

   
   

6. Hou Q, Tang J, Wang Z, et al. Inhibitory effect of microRNA-34a on retinal pigment epithelial cell proliferation and migration. Invest Ophthalmol Vis Sci. 2013;54:6481-6488.

   
   

7. Chen X, He D, Dong XD, et al. MicroRNA-124a is epigenetically regulated and acts as a tumor suppressor by controlling multiple targets in uveal melanoma. Invest Ophthalmol Vis Sci. 2013;54:2248-2256.

   
   

8. Yan D, Dong XD, Chen X, et al. Role of MicroRNA-182 in Posterior Uveal Melanoma: Regulation of Tumor Development through MITF, BCL2 and Cyclin D2. PLoS One. 2012;7:e40967.

   
   

9. Chen X, Wang J, Shen H, et al. Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma. Invest Ophthalmol Vis Sci. 2011;52:1193-1199.

   
   

10. Wang Z, Jin C, Li H, et al. GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation. FEBS Lett. 2010;584:4057-4062.

    
    

11. Yan D, Zhou X, Chen X, et al. MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest Ophthalmol Vis Sci. 2009;50:1559-1565.

    
    

12. Yan D, Dong Xda E, Chen X, et al. MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development. J Biol Chem. 2009;284:29596-29604.

    
    

13. Wang ZY, Shen LJ, Tu L, et al. Erythropoietin protects retinal pigment epithelial cells from oxidative damage. Free Radic Biol Med. 2009;46:1032-1041.

    
    

14. Jin X, Qin Q, Tu L, Qu J. Glucocorticoids inhibit the innate immune system of human corneal fibroblast through their suppression of toll-like receptors. Mol Vis. 2009;15:2435-2441.

    
    

15. Weng J, Luo J, Cheng X, et al. Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008;105:6081-6086.

    
    

16. Jin C, Yin F, Lin M, et al. GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development. Invest Ophthalmol Vis Sci. 2008;49:4245-4253.