Talent Recruitment

Publication and Fundings

1.Xie H., Ge X., Yang F., Wang B., Li S., Duan J., Lv X., Cheng C., Song Z., Liu C., Zhao J., Zhang Y., Wu J., Gao C., Zhang J. #, and Gu F.#, High-fidelity SaCas9 identified by directional screening in human cells. Plos Biology, 2020; 18(7)e3000747.
2.Lv X., Qiu K., Tu T., He X., Peng Y., Ye J., Fu J., Deng R., Wang Y., Wu J., Liu C., Zhao J. #, and Gu F. #, Development of a Simple and Quick Method to Assess Base Editing in Human Cells. Molecular therapy. Nucleic acids, 2020. 20: p. 580-588.
3.He X., Wang Y., Yang F., Wang B., Xie H., Gu L., Zhao T., Liu X., Zhang D., Ren Q., Liu X., Liu Y., Gao C., and Gu F. #, Boosting activity of high-fidelity CRISPR/Cas9 variants using a tRNA(Gln)-processing system in human cells. Journal of Biological Chemistry, 2019. 294(23): p. 9308-9315.
4.Lin L., He X., Zhao T., Gu L., Liu Y., Liu X., Liu H., Yang F., Tu M., Tang L., Ge X., Liu C., Zhao J., Song Z., Qu J., & Gu F.#, Engineering direct repeat sequence of crRNA for optimization of FnCpf1-mediated genome editing in human cells. Molecular therapy. 2018.
5.Sun H., Li F., Liu J., Yang F., Zeng Z., Lv X., Tu M., Liu Y., Ge X., Liu C., Zhao J., Zhang Z., Qu J., Song Z. & Gu F.#, A Single Multiplex crRNA Array for FnCpf1-Mediated Human Genome Editing. Molecular therapy, 2018.26:2070-2076.
6.Wang Y., Li H., Zang S., Li F., Chen Y., Zhang X., Song Z., Peng Q. & Gu F.#, Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage. Investigative ophthalmology & visual science, 2018,59:1810-1821.
7.Xie H., Tang L., He X., Liu X., Zhou C., Liu J., Ge X., Li J., Liu C., Zhao J., Qu J., Song Z.#& Gu F.#, SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells. Biotechnology journal, 2018,13:e1800080.(Cover story)
8.Tu M., Lin L., Cheng Y., He X., Sun H., Xie H., Fu J., Liu C., Li J., Chen D., Xi H., Xue D., Liu Q., Zhao J., Gao C., Song Z., Qu J. & Gu F.#, A 'new lease of life': FnCpf1 possesses DNA cleavage activity for genome editing in human cells. Nucleic acids research, 2017,45:11295-11304.
9.Yang F., Liu C., Chen D., Tu M., Xie H., Sun H., Ge X., Tang L., Li J., Zheng J., Song Z., Qu J. & Gu F.#, CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool. Molecular therapy. Nucleic acids, 2017,7:378-386.
10.Ge, X., Xi, H., Yang, F., Zhi, X., Fu, Y., Chen, D., Xu, R. H., Lin, G., Qu, J., Zhao, J. #, and Gu F.#, CRISPR/Cas9-AAV Mediated Knock-in at NRL Locus in Human Embryonic Stem Cells. Molecular therapy. Nucleic acids. 2016. 5(11): e393
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