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Research Interests

Molecular Neurobiology of Cortical and Visual Abnormalities in Autism
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that occurs early in children. The clinical features of ASD include language barriers, deficits in social -emotional reciprocity, repeated stereotypes, and visual abnormalities. FOXP1 and FOXP2 are genes implicated in developmental speech and language disorders, and mutations of FOXP1 cause intellectual disability and ophthalmological abnormalities with autistic features. By in utero electroporation technique combined with the mutant mice, we study 1) Expression and function of Foxp1 in the retina and visual cortex. 2) Regulation of migration, autophagy, membrane secretion, and mitosis by Foxp1 and other ASD-related genes in the neuronal cells. These studies may improve our understanding of the complex relationships between gene mutation and the brain and visual disorders.
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